大連醫科大學基礎醫學院導師：秘曉林 正文

[導師姓名]
秘曉林

[所屬院校]
大連醫科大學

[基本信息]
導師姓名：秘曉林
性別：
人氣指數：1230
所屬院校：大連醫科大學
所屬院系：基礎醫學院
職稱：教授
導師類型：博導
招生專業：
研究領域：1.DNA損傷導致的細胞周期調節、凋亡、轉錄調控的機制；2.非編碼RNA（miRNA和ln...

[通訊方式]
辦公電話：0411-86110513
電子郵件：[email protected]

[個人簡述]
秘曉林，博士，教授，博士生導師。
大連醫科大學基礎醫學院副院長，生物科學系主任。入選中國科學 院“引進國外杰出人才--百人計劃”，遼寧省“攀登學者”。國家科技
獎、國家重大科學研究計劃、自然科學基金、博士后科學基金、美 國國家科學基金研究生項目等評議人，SCI雜志International Journal of Nanomedicine顧問編委，Journal of Biochemistry and Molecular Biology Research編委，中國生化藥物雜志編委，中國環境誘變劑學 會理事，Biomaterials、Genetics、Environmental Toxicology and Pharmacology、International Journal of Nanomedicine、PLoS One等 雜志審稿人。主持國家重點基礎研究計劃“973”項目課題、自然科 學基金面上項目、中國科學院創新項目等。 1990年畢業于蘭州大學，獲生物化學學士學位。1996年畢業于衛生 部蘭州生物制品研究所，獲免疫學和微生物學碩士學位。1999年畢
業于中國預防醫學科學院病毒學研究所，獲病原生物學博士學位。 同年赴美國，在國立衛生研究院（National Institutes of Health）癌 癥研究所（National Cancer Institute）從事博士后研究，隨后任職美
國國立衛生研究院癌癥研究所高級研究學者。作為通訊作者，研究 成果發表在Proceedings of National Academy of Sciences USA, Oncogene, Human Molecular Genetics, Biomaterials, Journal of Cell Science, Nanotoxicology等國際一流學術期刊。

[科研工作]
代表性文章（*通訊作者）
1. Li D., Liu Y., Pei C., Zhang P., Pan L., Xiao J., Meng S., Yuan Z., Bi X. *A miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in Drosophila. Proceedings of National Academy of Sciences USA. 2017. (In press) IF 9.4
2. Cong W., Wang P., Qu Y., Tang J., Bai R., Zhao Y., Chen C. , Bi X. * Evalutation of the influence of Fullerenol on aging and stress resistance using Caenorhabditis elegans. Biomaterials. 2015. 42:78-86. IF 8.6 3. Jiang K., Liu M., Lin G., Mao B., Cheng W., Liu H., Gal J., Zhu H., Yuan Z., Deng W., Liu Q., Gong P., Bi X. *, Meng S. * Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death. Oncotarget. 2016. 7 (18): 25652-25667. IF 5.0 4. Qian X., Wang P., Xia Y., Dou T., Jin Q., Wang D., Hao D., Bi X. *, Ge G. *, Yang L.* A highly selective fluorescent probe for sensing activities of catechol-O-methyltransferase in complex biological samples. Sensors and Actuators B. 2016. 231:615–623. IF 4.8 5. Chen H., Wang B., Feng W., Du W., Ouyang H., Chai Z., Bi X.* Oral Magnetite Nanoparticles Disturb the Development of Drosophila Melanogaster from Oogenesis to Adult Emergence. Nanotoxicology. 2015. 9(3):302-312. IF 7.9 6. Yuan Q., Han J., Cong W., Ge Y., Ma D., Dai Z., Li Y., Bi X. * Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with improved cell apoptosis and gene expression profile and reduced myelosuppression toxicity. International Journal of Nanomedicine. 2014. 9(1): 4829-4846. IF 4.3 7. Fang G., Zhang D., Yin H., Zheng L., Bi X.*, Yuan L.* Centlein maintains centrosome cohesion by bridging an interaction between C-Nap1 and Cep68. Journal of Cell Science. 2014. 127:1631-1639. IF 5.4 8. Wang Y., Wang Z., Joshi BH., Puri R., Stultz B., Yuan Q., Bai Y., Zhou P., Yuan Z., Hursh DA., Bi X.* The tumor suppressor Caliban regulates DNA damage induced apoptosis through p53-dependent and –independent activity. Oncogene. 2013. 32(33):3857-66. IF 8.6 9. Liu W., Jiang F., Bi X.*, Zhang Q*. Drosophila FMRP participates in DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. Human Molecular Genetics. 2012, 21(21):4655-68. IF 7.7 10. Kong L., Yuan Y., Zhu H., Li Y., Guo Q., Zhao Y., Wang Q., Bi X.*, Gao X*. The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis. Biomaterials. 2011.32(27)：6515-6522. IF 7.6 11. Wang P., Bai Y., Song B., Wang Y., Liu D., Lai Y., Bi X.*, Yuan Z*. PP1A-mediated dephosphorylation positively regulates YAP2 activity. PLoS ONE. 2011.6(9):e24288. IF 4.3 12. Gao G., Bi X., Chen J., Srikanta D., Rong YS. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. Proc. Nat. Acad. Sci. USA. 2009. 106(26): 10728–10733.(Equal contribution). IF 9.4 13. Bi X., Jones T., Abbasi F., Lee H., Stultz B., Hursh D., Mortin M. Drosophila Caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Oncogene. 2005. 24:8229-8239. IF 6.8 14. Bi X., Srikanta D., Fanti L., Pimpinelli S., Badugu R., Kellum R., Rong Y.S. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proc. Nat. Acad. Sci. USA. 2005. 102(42):15167-15172. IF 10.2 15. Bi X., Gong M., Srikanta D., Rong Y.S. Drophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation. Genetics. 2005. 171:845-847. IF 4.4 16. Bi X., Wei S.D., Rong Y.S. Telomere protection without a telomerase: the role of ATM and Mre11 in Drosophila telomere maintenance. Current Biology. 2004. 14:1348-1353. IF 11.9 17. Bi X., Kajava A., Demidenko Z., Jones T., Mortin M. The carboxyl terminus of Prospero regulates its subcellular localization. Molecular and Cellular Biology. 2003. 23 (3): 1014-1024. IF 8.9

[教育背景]

大連醫科大學

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