天津科技大學生物工程學院導師：滿淑麗 正文

[導師姓名]
滿淑麗

[所屬院校]
天津科技大學

[基本信息]
導師姓名：滿淑麗
性別：女
人氣指數：1229
所屬院校：天津科技大學
所屬院系：生物工程學院
職稱：副教授
導師類型：
招生專業：藥理學
研究領域：[1]天然產品的提取分離與活性研究；[2]中藥成分鑒定及體內代謝研究；[3]中藥組方配伍機...

[通訊方式]
辦公電話：022-60601265
電子郵件：[email protected]
通訊地址：天津經濟技術開發區第十三大街29號天津科技大學生物工程學院

[個人簡述]


[科研工作]
長期從事天然產物成分分離鑒定及活性開發等研究，參與課題多項，其中主持國家及省部級項目3項。尤其是對甾體皂苷類成分的鑒定抗腫瘤成藥性作用機制的闡述安全性等方面開展了一系列研究。相關成果包括作為第一作者或通訊作者發表SCI論文40余篇；其中一二區論文20篇，累積影響因子120；目前論文累積引用八百余次，單篇最高引用280次。近五年發表的主要學術論文有：[1]Man SL* Zhang LL Cui JX Yang L Ma L Gao WY*. Curcumin enhances the anti-cancer effects of Paris Saponin II in lung cancer cells. Cell Proliferation. 2018: e12458.[2]Man SL* Chai HY Cui JX Yao JW Ma L Gao WY*. Antitumor and anti-metastatic mechanisms of Rhizoma paridis saponins in Lewis mice. Environmental Toxicology. 2018 33(2): 149-155.[3]Man SL Ma J Yao JW Cui JX Wang CX Li Y Ma L* Lu FP*. Systemic perturbations of key metabolites in Type 2 diabetic rats treated by polyphenols extracts from Litchi chinensis seeds. J Agric Food Chem. 2017 65(35):7698-704[4]Man SL* Li J Qiu PY Liu J Liu Z Ma L Gao WY*. Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins. Molecular Carcinogenesis. 2017 56:1405-13.[5]Man SL Qiu PY Li J Zhang LM Gao WY*. Global metabolic profiling for the study of Rhizoma Paridis Saponins induced hepatotoxicity in rats. Environmental Toxicology. 2017 32:99-108.[6]Qiu PY Sun JC Man SL* Yang H Ma L Yu P Gao WY*. Curcumin attenuates N- nitrosodiethylamine induced liver injury in mice by utilizing the method of metabonomics. J Agric Food Chem. 2017 65 (9) 2000-7.[7]Man SL Li J Liu J Fan W Liu Z Wang JM Gao WY*. Curcumin alleviated the toxic reaction of Rhizoma paridis saponins in a 45-day subchronic toxicological assessment of rats. Environmental Toxicology. 2016 31: 1935-43.[8]Qiu PY Man SL* Yang H Fan W Yu P Gao WY*. Utilization of metabonomics to identify serum biomarkers in murine H22 hepatocarcinoma and deduce antitumor mechanism of Rhizoma Paridis saponins. Chemico-biological interactions. 2016 256: 55-63.[9]Qiu PY Man SL* Li J Liu J Zhang LM Yu P Gao WY*. Overdose Intake of Curcumin Initiates the Unbalanced State of Bodies. J Agric Food Chem. 2016 64: 2765-71.[10]Qiu PY Man SL* Yang H Liu YX Liu Z Ma L Yu P Gao WY*. Metabolic regulatory network alterations reveals different therapeutic effects of cisplatin and Rhizoma paridis saponins in Lewis pulmonary adenoma mice. RSC Advances. 2016 6: 115029 - 38.[11]Liu J Liu Z Man SL* Chai HY Ma L Gao WY*. Inhibition of urethane-induced lung carcinogenesis in mice by Rhizoma paridis saponins involved EGFR/PI3K/Akt pathway. RSC Advances. 2016 6: 92330 - 4.[12]Liu J Man SL* Liu Z Ma L Gao WY*. A synergistic antitumor effect of Polyphyllin I and Formosanin C on hepatocarcinoma cells. Bioorganic & Medicinal Chemistry Letters. 2016 26: 4970-5.[13]Liu J Man SL* Li J Zhang Y Meng X Gao WY*. Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin. Environmental Toxicology and Pharmacology. 2016 46: 103-9.[14]Zhang LL Man SL* Qiu HN Liu Z Zhang M Ma L Gao WY*. Curcumin-cyclodextrin complexes enhanced the anti-cancer effects of curcumin. Environmental Toxicology and Pharmacology. 2016 48: 31-8.[15]Zhang LL Man SL* Wang YS Liu J Liu Z Yu P Gao WY*. Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells. Chemico-Biological Interactions. 2016 253: 125-133.[16]Li J Man SL* Qiu PY Fan W Zhang LM Gao WY*. Toxicological risks of Rhizoma Paridis saponins in rats involved NF-κB and Nrf2 signaling. RSC Advances. 2016 6: 31889-31897.[17]Man SL* Ma J Wang CX Li Y Gao WY Lu FP*. Chemical composition and hypoglycaemic effect of polyphenol extracts from Litchi chinensis seeds. J Funct Foods. 2016 22: 313-24.[18]Man SL Li J Fan W Chai HY Liu Z Gao WY*. Inhibition of pulmonary adenoma in diethylnitrosamine-induced rats by Rhizoma paridis saponins. J Steroid Biochem Mol Biol. 2015 154: 62-67.[19]Man SL Chai HY Qiu PY Fan W Liu Z Wang JM Gao WY*. Turmeric enhancing anti-tumor effect of Rhizoma paridis saponins by influencing their metabolic profiling in tumors of H22 hepatocarcinoma mice. Pathol Res Pract. 2015 211: 948-54.[20]Li YY Man SL* Li J Chai HY Fan W Liu Z Gao WY*. The antitumor effect of formosanin C on HepG2 cell as revealed by 1H-NMR based metabolic profiling. Chemico-Biological Interactions. 2014 220C: 193-9.[21]Man SL Fan W Liu Z Gao WY Li YY Zhang LM Liu CX. Antitumor pathway of Rhizoma Paridis Saponins based on the metabolic regulatory network alterations in H22 hepatocarcinoma mice. Steroids. 2014 84:17-21.[22]Man SL Li YY Fan W Gao WY Liu Z Zhang Y Liu CX. Combination therapy of cyclophosphamide and Rhizoma Paridis Saponins on anti-hepatocarcinoma mice and effects on cytochrome p450 enzyme expression. Steroids. 2014 80:1-6.[23]Man SL Fan W Gao WY Li YY Wang Y Liu Z Li HF. Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats. J Ethnopharmacol. 2014 151:407-412.

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